The brain’s crucial ‘stop eating’ signal appears to originate from an unlooked-for cellular player. Recent scientific investigations have unveiled that astrocytes, previously considered mere support cells for neurons, hold a pivotal function in regulating appetite. Following a meal, the presence of glucose stimulates tanycytes. These tanycytes, in turn, transmit signals to astrocytes, which subsequently activate the neurons responsible for generating feelings of satiety. This newly identified neural pathway offers promising avenues for developing groundbreaking therapies for obesity and various eating disorders.

